The Genesis Mission: America’s New AI-Powered Scientific Engine

President Donald Trump has launched an ambitious new initiative called the Genesis Mission, an executive order designed to harness artificial intelligence and advanced computing to revolutionize scientific research in the United States. Led by the Department of Energy, this transformative program aims to double the productivity and impact of American science and engineering within the next decade.

A Centralized Platform for Data and Discovery

At the core of the Genesis Mission is a centralized AI platform that will integrate decades of federal research data with cutting-edge computing infrastructure. The platform will house massive datasets collected over years of federal investments, combined with data from academic institutions and private sector partners. These unified data resources will be leveraged to train scientific foundation models and power AI agents that can automate research workflows and accelerate breakthrough discoveries.

The platform represents an unprecedented collaboration, connecting the nation’s most advanced supercomputers, AI systems, and next-generation quantum technology with America’s most sophisticated scientific instruments.

Infrastructure and Implementation

Hewlett Packard Enterprises is building two sovereign AI supercomputers at Oak Ridge National Laboratory, powered by AMD chips, which will serve as the flagship computing backbone for the initiative. The Department of Energy has been tasked with identifying its initial data and model assets within four months, with a goal to demonstrate an initial operating capability addressing at least one national science and technology challenge within nine months.

Strategic Focus Areas

The Genesis Mission prioritizes three critical domains: accelerating nuclear and fusion energy while modernizing the energy grid through AI, powering scientific discoveries for the coming decades, and developing advanced AI technologies for national security, including systems to ensure the reliability of America’s nuclear arsenal and accelerate materials development for defense applications.

The program also targets breakthrough research in biotechnology, critical materials, space exploration, quantum information science, and semiconductors and microelectronics, positioning the United States to maintain its competitive edge in the global AI race and tackle challenges previously thought impossible.

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